Supportive Oligonucleotide Therapy (SOT)
SOT is a highly individualized therapy that aids the body in overcoming chronic bacterial infections, such a Lyme, or viral infections.
RGCC lab has facilities globally and offers advanced, cutting-edge testing and therapies for a wide range of infections and cancer.
What is the goal of SOT?
The Goal: Eliminate existing micro-organisms or cancer cells.
How does SOT work?
SOT works by shutting down the gene replication sequence of the target (cancer cell, virus, Lyme, etc.) eliminating the next life cycle for that cell or organism so it will not be able to reproduce. It creates a 98% specificity to the target genes and does so by creates a string of nucleotides that bind to the RNA of the organism to preventing this from being translated into proteins. It is very efficient at silencing genes that are critical for the microbes’ survival. SOT can help kill the microbes without interfering with our bodies own DNA.
It is administered as a single dose IV and remains active in the system for up to six months inhibiting the replication cycle of the target. This is not an immune therapy.
Depending on the patient, patients may only need one SOT, or they may benefit from additional SOT’s for the same microbe or additional microbes.
How long has SOT therapy been around as a treatment?
SOT therapy is not new and has been assessed in thousands of studies for safety. It has been around for over 10 years and began at the RGCC labs in Greece. There are years of research behind these therapies from both companies and universities in European and American.
Here are some studies of interest:
https://doi.org/10.1002/(SICI)1097-4652(199911)181:2%3C251::AID-JCP7%3E3.0.CO;2-D
https://pubs.rsc.org/en/content/articlehtml/2020/ra/d0ra04978f
https://www.annualreviews.org/doi/abs/10.1146/annurev-med-041217-010829
https://www.tandfonline.com/doi/full/10.1080/17425255.2021.1992382#
https://www.nature.com/articles/nrneurol.2017.148
https://wires.onlinelibrary.wiley.com/doi/abs/10.1002/wrna.1594
https://www.mdpi.com/612152
https://journals.sagepub.com/doi/abs/10.1177/1756286418776932
https://www.sciencedirect.com/science/article/abs/pii/S1359644617300430
What infections are SOT good for?
• Tickborne Illnesses: 24 species of Lyme disease and co-infections such as Babesia and Bartonella.
• Viral infections: Epstein-Barr Virus (EBV), Coxsackie virus, Cytomegalovirus (CMV), Hepatitis B and C, HHV 1, 2 and 6, HIV, HPV 6, 11, 16 and 18, HTLV1, and Shingles.
How is SOT administered?
SOT is administered one time intravenously (IV). The two other medications administered with the SOT include dexamethasone and an H2 blocker, such as famotidine.
Some patients only need one treatment, while other patients may need additional SOTs for the same organisms or may opt to receive SOT treatments for other organisms. You can receive a subsequent SOT for the same organisms every three months, or up to three in one year. If receiving two different SOTs for two different organisms these are typically spaced apart by at least one month.
What is the process to receive this therapy?
To receive SOT through our clinic, here is a brief overview of the steps:
Step 1: Because of how specialized this therapy, is you, must have an established patient visit with our provider first to help create the best plan for you. There must be a positive test for the organism from a credible lab (Igenex, vibrant, etc) within 6 months. We can utilize labs that you have already had drawn or we are happy to draw the labs at our clinic.
Step 2: Once we have a positive test and decide on the organism, we draw your blood and send this off to Greece to RGCC. They get to work to create the SOT specifically for your organisms.
Step 3: It typically, takes several weeks for Greece to create the SOT and send this back to us. In the meantime, Dr. Saxton has patients do specific personalized detoxification and bio-terraine optimization to be able to benefit the most once they receive the SOT. This will be discussed in detail at your appointment.
Step 4: Once we receive the SOT back from Greece, we are able to then administer this via an IV. There are two medications administered with the SOT- one is dexamethasone, and the other is an H2 blocker, such as famotidine.
Once this is administered, it gets to work inhibiting pathogen replication, 24 hours a day, 7 days a week for up to 6 months.
What are the side effects of SOT?
While SOT is typically very well tolerated, when dealing with living pathogens in a human body there are potential side effects even with a gene silencing therapy like SOT.
Some of the common side effects include:
• Headaches
• Increased fatigue
• Flu like symptoms
• In Lyme or viral – Herxheimer reactions can occur
• In Lyme or viral – co-infections can flare
There are some pre and post treatment measures that can help mitigate these side effects.
What are the contra-indications for this therapy?
Reasons why a patient would not be eligible for this therapy include some of the following:
o Recent chemotherapy or radiation treatment (within 14 days)
o Radioactive seed therapy
o Delta T Cell Therapy
o Recent blood transfusions (within 120 days)
o Cachexia
o Pregnancy or breast feeding
o Children under 11 when used for the treatment of cancer
o Children under 5 when used for the treatment of Lyme
What is the cost of SOT at Roots Integrative Medicine?
The fee of SOT fluctuates by the month depending on the dollar-euro conversion. Please contact us for more information.
What are the statistics regarding clinical improvements after treatment with SOT?
According RGCC and their analysis, they have observed the following:
• Virus Infected Patients: The positive clinical outcome reached 91%
• Lyme Disease: Approximately 95% of cases had a positive clinical outcome (stats include
Borrelia, Bartonella and Babesia)
